Addiction, Diablo 3, and Portal 2

In The Tipping Point, Malcolm Gladwell talks about nicotine addiction amongst smokers. What you might not know is that nicotine's power varies quite a bit depending on the, uh, victim.

Of all the teenagers who experiment with cigarettes, only about a third ever go on to smoke regularly. Nicotine may be highly addictive, but it is only addictive in some people, some of the time. More important, it turns out that even among those who smoke regularly, there are enormous differences in the stickiness of their habit. Smoking experts used to think 90 to 95 percent of all those who smoked were regular smokers. But several years ago, the smoking questions on the federal government's national health survey were made more specific, and researchers discovered, to their astonishment, that a fifth of all smokers don't smoke every day. There are millions of Americans, in other words, who manage to smoke regularly and not be hooked—people for whom smoking is contagious but not sticky.

Gladwell goes on to call these sometimes-smokers "chippers." While chippers never feel the need to go beyond a certain level of their drug, true addicts escalate their drug usage over time. I was surprised when I first read that, as I would have imagined that everyone would be caught on the slippery slope toward needing more and more of a drug, but apparently not.

You might ask what separates chippers from more hardcore addicts. In Gladwell's summary of the situation, he says "probably genetic factors." One piece of support for this is a (kind of scary) study where mice were given toxic levels of nicotine. At some point, it's poisonous enough to cause a seizure. Is that point about the same in all mice? Turns out, it's not. While some mice had seizures at X amount of nicotine, other mice could tolerate two or three times that amount. There seems to be a genetic difference here. Further, that range of "toxic to some, but others can tolerate two or three times as much" is the same range for alcohol.

I've never personally been interested in smoking (or drinking alcohol, for that matter), but I drink coffee. It's something I originally did for practical reasons when I needed a bit of a boost to do some work, even though I didn't want the coffee at all, but now I certainly have some sort of chemical addition to it. That said, it's only at the level of a "chipper." I have basically never had more than one coffee in a day, while I know others who have escalated to four, five, six cups, etc.

Oh, and another thing about those mice. The experimenters wondered whether there was a correlation between how much nicotine a mice could tolerate (a genetic factor) and how much nicotine the mouse would *voluntarily* consume (behavioral factor). It turns out the correlation was almost perfect, and that the more a given mouse could tolerate, the more it voluntarily consumed. So I'm willing to be my own personal choice of having some coffee, but not nearly as much as some other people I know, is just my luck of the draw with genetics.

Wanting vs Liking

If you only read one thing in this post, this should be it: "wanting" and "liking" are governed by different circuits in the brain, based on different chemicals. (The wanting-circuit uses dopamine while the liking-circuit uses opioids.) It's actually super important for you to know that wanting and liking are so different in our brains. Things that you want are not necessarily things you will like. This illuminates how bad of an idea it is to expend huge amounts of effort to attain things that you will ultimately not like. The most obvious one here is money. Mountains of research say that

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